The amino acid 5-HTP is a natural, safe and effective treatment of anxiety

The brain needs L-tryptophan and 5-hydroxytryptophan (5-HTP) to manufacture serotonin

L-tryptophan and 5-HTP are widely used alternative treatments of generalized anxiety. Both amino acids are essential for manufacture of serotonin in the brain. Serotonin is a neurotransmitter that plays a central role in the regulation of mood and anxiety. Greater research evidence supporting the use of 5-HTP for anxiety, together with smaller effective doses and increased CNS availability generally make 5-HTP the preferred choice over L-tryptophan.

5-HTP reduces the severity of generalized anxiety  

More research has been done on 5-HTP than l-tryptophan. In a double-blind study, 58% of generally anxious patients (79 total subjects) randomized to L-tryptophan 3 grams per day reported significantly greater reduction in baseline anxiety compared to individuals who received a placebo. Both animal studies and human clinical trials show that 5-HTP has anti-anxiety effects. There is some evidence that 5-HTP may inhibit panic attacks induced by carbon dioxide.

Uses of 5-HTP in integrative psychiatry

In the rapidly growing field of integrative psychiatry prescription medications and natural supplements are often used in combination to improve treatment response and reduce side effects when medications are taken alone. 5-HTP is an example of a natural supplement that may be safely combined with a prescription anti-anxiety medication with little risk of adverse effects. In one study patients randomized to 5-HTP in combination with carbidoba (a drug that inhibits the enzyme that breaks down 5-HTP in the peripheral blood supply, thus increasing the amount of 5-HTP that enters the brain) reported reductions in anxiety comparable to patients treated with an anti-anxiety medication. In contrast, patients who received a placebo did not improve. 

Starting 5-HTP at a low dose reduces the risk of side effects

Some individuals who take 5-HTP report daytime fatigue or sleepiness. There have been infrequent reports of mild serotonin syndrome, a condition caused by excessive brain serotonin associated with insomnia, agitation and nervousness. The risk of serotonin syndrome and other adverse effects is minimized when 5-HTP is started at low doses such as 25 milligrams per day and gradually increased over several weeks to a daily regimen that is well tolerated and produces beneficial anti-anxiety effects.

In over 20 years of experience as an integrative psychiatrist I have found that 5-HTP 50 milligrams to 100 milligrams taken three times a day is a safe and effective approach for chronic generalized anxiety that is well tolerated without excessive daytime sedation. 5-HTP may be taken alone or in combination with anti-anxiety medications.

Taking 5-HTP at bedtime improves sleep and reduces daytime anxiety

Gradually increasing a bedtime dose of 5-HTP from 50 milligrams to 200 to 300 milligrams over a period of 2 to 3 weeks often improves the quality of sleep in chronically anxious patients who complain of insomnia while also reducing the severity of daytime anxiety.

Finding a quality brand of 5-HTP

When considering taking 5-HTP or any natural supplement it is important to find a quality brand known to be both effective and safe. I do not recommend particular brands to my patients. However my website includes links to web resources that will help you identify quality brands. 

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